BB 562: Cell Cycle Regulation

This course focuses on molecular events that regulate cell cycle transitions and their relevance to mammalian differentiated and undifferentiated cells. Topics include control of the Gl/S and G2/M transitions, relationships between tumor suppressor genes such as pi6, Rb, p53 or oncogenes such as cyclin D, cdc25A, MDM2 or c-myc and cell cycle control. Where appropriate, the focus is on understanding regulation of cell cycle control through transcriptional induction of gene expression, protein associations, posttranslational modifications like phosphorylation or regulation of protein stability like ubiquitin degradation. Students may receive credit for either BB562 or a BB570 course entitled Cell Cycle Regulation but not both.